fMRI

Combining brain perturbation and neuroimaging in non-human primates

Brain perturbation studies allow detailed causal inferences of behavioral and neural processes. Because the combination of brain perturbation methods and neural measurement techniques is inherently challenging, research in humans has predominantly …

Accelerating the Evolution of Nonhuman Primate Neuroimaging

Nonhuman primate neuroimaging is on the cusp of a transformation, much in the same way its human counterpart was in 2010, when the Human Connectome Project was launched to accelerate progress. Inspired by an open data-sharing initiative, the global …

Interindividual Variability of Functional Connectivity in Awake and Anesthetized Rhesus Macaque Monkeys

Background Nonhuman primate (NHP) models are commonly used to advance our understanding of brain function and organization. However, to date, they have offered few insights into individual differences among NHPs. In large part, this is due to the …

Verbal Fluency Is Affected by Altered Brain Lateralization in Adults Who Were Born Very Preterm

Language difficulties have been reported in children and adolescents who were born very preterm (textless32 weeks’ gestation) and associated with an atypical lateralization of language processing, i.e., increased right-hemispheric engagement. This …

An Open Resource for Non-human Primate Imaging

Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades …

Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis

While psychotic experiences (PEs) are assumed to represent psychosis liability, general population studies have not been able to establish significant associations between polygenic risk scores (PRS) and PEs. Previous work suggests that PEs may only …

A multimodal imaging study of recognition memory in very preterm born adults

Very preterm (textless32 weeks of gestation) birth is associated with structural brain alterations and memory impairments throughout childhood and adolescence. Here, we used functional MRI (fMRI) to study the neuroanatomy of recognition memory in 49 …

Altered resting-state functional connectivity in emotion-processing brain regions in adults who were born very preterm

Background Very preterm birth (VPT; textless32 weeks of gestation) has been associated with impairments in emotion regulation, social competence and communicative skills. However, the neuroanatomical mechanisms underlying such impairments have not …

Very Early Brain Damage Leads to Remodeling of the Working Memory System in Adulthood: A Combined fMRI/Tractography Study

Children who have brain injury following preterm birth often have working memory problems. When we assessed adults with the same injury, we found they no longer had severe working memory difficulties. By combining techniques to investigate the …

Road work on memory lane—Functional and structural alterations to the learning and memory circuit in adults born very preterm

Very preterm (VPT) birth is considered a risk factor not only for neurological impairment, but also for reduced function in several cognitive domains in childhood and later in life. Individuals who were born VPT are more likely to demonstrate …